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PtrA 是一种参与铜耐受的铜绿假单胞菌周质蛋白。

PtrA is a periplasmic protein involved in Cu tolerance in Pseudomonas aeruginosa.

机构信息

Bacterial Pathogenesis and Cellular Responses, iRTSV, CEA-Grenoble, Grenoble cedex 09, France.

出版信息

J Bacteriol. 2011 Jul;193(13):3376-8. doi: 10.1128/JB.00159-11. Epub 2011 Apr 29.

DOI:10.1128/JB.00159-11
PMID:21531801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3133295/
Abstract

In this work, we demonstrate that PtrA (U. H. Ha et al., Mol. Microbiol. 54:307-320, 2004) is a periplasmic protein, specifically synthesized in the presence of copper, that is involved in the tolerance of Pseudomonas aeruginosa to copper. Our biochemical and genetic analyses challenge its role in transcriptional inhibition of the type III secretion system.

摘要

在这项工作中，我们证明了 PtrA（U. H. Ha 等人，Mol. Microbiol. 54:307-320, 2004）是一种周质蛋白，在铜存在的情况下特异性合成，参与铜对铜绿假单胞菌的耐受性。我们的生化和遗传分析挑战了它在 III 型分泌系统转录抑制中的作用。

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本文引用的文献

1
ExsD inhibits expression of the Pseudomonas aeruginosa type III secretion system by disrupting ExsA self-association and DNA binding activity.ExsD 通过破坏 ExsA 的自缔合和 DNA 结合活性来抑制铜绿假单胞菌 III 型分泌系统的表达。
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2
Anti-activator ExsD forms a 1:1 complex with ExsA to inhibit transcription of type III secretion operons.抗激活因子ExsD与ExsA形成1:1复合物，以抑制III型分泌操纵子的转录。
J Biol Chem. 2009 Jun 5;284(23):15762-70. doi: 10.1074/jbc.M109.003533. Epub 2009 Apr 15.
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Control of gene expression by type III secretory activity.通过III型分泌活性对基因表达的调控。
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Survival and growth in the presence of elevated copper: transcriptional profiling of copper-stressed Pseudomonas aeruginosa.在铜含量升高的环境中的存活与生长：铜胁迫下铜绿假单胞菌的转录谱分析
J Bacteriol. 2006 Oct;188(20):7242-56. doi: 10.1128/JB.00837-06.
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Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system.铜绿假单胞菌Ⅲ型分泌系统的转录调控
Mol Microbiol. 2006 Nov;62(3):631-40. doi: 10.1111/j.1365-2958.2006.05412.x. Epub 2006 Sep 21.
6
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