SA11轮状病毒受到乙酰化唾液酸的特异性抑制。
SA11 rotavirus is specifically inhibited by an acetylated sialic acid.
作者信息
Willoughby R E, Yolken R H
机构信息
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
出版信息
J Infect Dis. 1990 Jan;161(1):116-9. doi: 10.1093/infdis/161.1.116.
Bovine salivary mucin (BSM) inhibits rotavirus replication in vitro and in vivo. The inhibitory effect of BSM in vitro is abolished by Arthrobacter ureafaciens neuraminidase but not by Clostridia perfringens neuraminidase; it is abolished by mild base deacetylation but not by influenza C acetylesterase. The data suggest that SA11 rotavirus binds to a specific sialic acid structure on BSM different from the sialic acids recognized by other viruses.
牛唾液粘蛋白（BSM）在体外和体内均能抑制轮状病毒复制。尿道节杆菌神经氨酸酶可消除BSM在体外的抑制作用，而产气荚膜梭菌神经氨酸酶则不能；轻度碱脱乙酰作用可消除该抑制作用，而丙型流感病毒乙酰酯酶则不能。数据表明，SA11轮状病毒与BSM上一种特定的唾液酸结构结合，该结构不同于其他病毒所识别的唾液酸。
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