潜在工业菌株多粘类芽孢杆菌 ATCC 12321 的新型（2R,3R）-2,3-丁二醇脱氢酶。
Novel (2R,3R)-2,3-butanediol dehydrogenase from potential industrial strain Paenibacillus polymyxa ATCC 12321.
机构信息
Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, 21071 Hamburg, Germany.
出版信息
Appl Environ Microbiol. 2011 Jun;77(12):4230-3. doi: 10.1128/AEM.02998-10. Epub 2011 Apr 29.
Abstract
A (2R,3R)-2,3-butanediol dehydrogenase (BDH99::67) from Paenibacillus polymyxa ATCC 12321 was functionally characterized. The genetic characteristics of BDH99::67 are completely different from those of meso- and (2S,3S)-2,3-butanediol dehydrogenases. The results showed that BDH99::67 belongs to the medium-chain dehydrogenase/reductase superfamily and not to the short-chain dehydrogenase/reductase superfamily, to which meso- and (2S,3S)-2,3-butanediol dehydrogenases belong.
摘要
从多粘类芽孢杆菌 ATCC 12321 中分离得到一种 (2R,3R)-2,3-丁二醇脱氢酶（BDH99::67），并对其进行了功能表征。BDH99::67 的遗传特征与 meso-和 (2S,3S)-2,3-丁二醇脱氢酶完全不同。结果表明，BDH99::67 属于中链脱氢酶/还原酶超家族，而不属于 meso-和 (2S,3S)-2,3-丁二醇脱氢酶所属的短链脱氢酶/还原酶超家族。
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