胱抑素C，一种人类蛋白酶抑制剂，可阻断单纯疱疹病毒的复制。
Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus.
作者信息
Björck L, Grubb A, Kjellén L
机构信息
Department of Medical Microbiology, University of Lund, Sweden.
出版信息
J Virol. 1990 Feb;64(2):941-3. doi: 10.1128/JVI.64.2.941-943.1990.
Abstract
Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.
摘要
胱抑素C是一种存在于细胞外液中的人半胱氨酸蛋白酶抑制剂。对胱抑素C和一种模拟其蛋白酶结合中心的三肽衍生物（Z-LVG-CHN2）进行了针对1型单纯疱疹病毒（HSV）和1型脊髓灰质炎病毒的抗病毒活性测试。重组胱抑素C和Z-LVG-CHN2均对HSV复制显示出强烈的抑制作用，而对脊髓灰质炎病毒复制未见明显影响。完全抑制HSV复制的胱抑素C的摩尔浓度低于Z-LVG-CHN2或阿昔洛韦（目前最常用于治疗HSV感染的药物）的摩尔浓度。这些结果表明，半胱氨酸蛋白酶抑制剂可能作为病毒复制抑制剂发挥生理作用，并且此类蛋白酶抑制剂或模拟其蛋白酶结合中心的肽衍生物可能用作抗病毒药物。
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