Elahi Maqsood, Mahmood Mohsin, Shahbaz Ahmad, Malick Naveed, Sajid Jawad, Asopa Sanjay, Matata Bashir M
Wessex Cardiothoracic Centre, General/ BUPA, Chalybeate Close, Southampton, SO16 6UY, United Kingdom.
Curr Cardiol Rev. 2010 May;6(2):104-11. doi: 10.2174/157340310791162640.
The pathophysiology of several conditions including heart failure is partly attributable to a failure of the cell energy metabolism. Studies have shown that exercise training (ET) improves quality of life (QOL) and is beneficial in terms of reduction of symptoms, mortality and duration of hospitalization. Increasingly, ET is now achieving acceptance as complimentary therapy in addition to routine clinical practice in patients with chronic heart failure (CHF). However, the mechanisms underlying the beneficial effects of ET are far less understood and need further evaluation. Evidence suggests that while CHF induces generalized metabolic energy depletion, ET largely enhances the overall function of the heart muscle. Hence, research efforts are now aiming to uncover why ET is beneficial as a complimentary treatment of CHF in the context of improving endothelial function and coronary perfusion, decreasing peripheral resistance, induction of cardiac and skeletal muscle cells remodeling, increasing oxygen uptake, substrate oxidation, and resistance to fatigue. Here we discuss the current evidence that suggest that there are beneficial effects of ET on cardiac and skeletal muscle cells oxidative metabolism and intracellular energy transfer in patients with CHF.
包括心力衰竭在内的几种病症的病理生理学部分归因于细胞能量代谢的失败。研究表明，运动训练（ET）可改善生活质量（QOL），并在减轻症状、降低死亡率和缩短住院时间方面有益。越来越多的是，ET现在作为补充疗法除了在慢性心力衰竭（CHF）患者的常规临床实践中也获得了认可。然而，ET有益效果的潜在机制了解得要少得多，需要进一步评估。有证据表明，虽然CHF会导致全身性代谢能量消耗，但ET在很大程度上增强了心肌的整体功能。因此，目前的研究工作旨在揭示为什么在改善内皮功能和冠状动脉灌注、降低外周阻力、诱导心肌和骨骼肌细胞重塑、增加氧摄取、底物氧化以及抗疲劳方面，ET作为CHF的补充治疗是有益的。在此我们讨论当前的证据，这些证据表明ET对CHF患者的心肌和骨骼肌细胞氧化代谢以及细胞内能量转移有有益作用。
