Department of Neurology and Psychiatry, Headache Centre, S. Andrea Hospital, Sapienza University, Via di Grottarossa, 1035-00189 Rome, Italy.
Neurol Sci. 2011 May;32 Suppl 1:S149-51. doi: 10.1007/s10072-011-0519-2.
The aim of the present study was to investigate the impact of comorbid migraine on quality of life (QoL) of patients with multiple sclerosis (MS). Forty-four MS patients with comorbid migraine and 44 sex/age-matched MS subjects free from primary headache were evaluated. Although we observed that comorbid migraine did not affect the physical and mental composite scores of the MS QoL-54 questionnaire, MS patients with migraine had worse scores than those without in role limitation due to physical problems (RL-P) (p = 0.035), bodily pain (BP) (p = 0.030) and health perception (HP) (p = 0.023) subscales. These findings were confirmed by multivariate regression analyses adjusted for demographic, clinical and psychometric variables. Significant correlations between MIDAS score and RL-P (r = -0.43, p = 0.003), BP (r = -0.51; p < 0.001), and HP (r = -0.38; p = 0.01) were also found. In conclusion, we suggest that investigating and treating migraine in MS patients might contribute to improve their QoL.
本研究旨在探讨偏头痛共病对多发性硬化症（MS）患者生活质量（QoL）的影响。评估了 44 例偏头痛共病的 MS 患者和 44 例性别/年龄匹配的无原发性头痛的 MS 患者。虽然我们观察到偏头痛共病并不影响 MS QoL-54 问卷的身心综合评分，但偏头痛患者在身体问题导致的角色受限（RL-P）（p=0.035）、躯体疼痛（BP）（p=0.030）和健康感知（HP）（p=0.023）亚量表的评分更差。这些发现通过调整人口统计学、临床和心理计量学变量的多变量回归分析得到了证实。MIDAS 评分与 RL-P（r=-0.43，p=0.003）、BP（r=-0.51；p<0.001）和 HP（r=-0.38；p=0.01）之间存在显著相关性。总之，我们建议调查和治疗 MS 患者的偏头痛可能有助于改善他们的 QoL。
