Fragoso Yára Dadalti, Finkelsztejn Alessandro, Gomes Sidney, Kaimen-Maciel Damacio Ramon, Oliveira Celso Luis S, Lopes Josiane, Cristovam Rafael A
Department of Neurology, Medical School, UNIMES and MS Reference Center DRS-IV, Santos SP, Brazil.
Arq Neuropsiquiatr. 2011 Apr;69(2A):180-3. doi: 10.1590/s0004-282x2011000200007.
The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS.
MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria.
In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter case-control study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls.
Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions.
不安腿综合征（RLS）在多发性硬化症（MS）中患病率的增加最近成为了几篇论文的主题。本研究调查了巴西四个城市中MS患者和对照组中RLS症状的患病率。此外，还针对RLS与MS这一主题进行了文献的系统评价和荟萃分析。
对MS患者和对照组就RLS的四种典型症状的存在情况进行了调查。对于呈现RLS症状四项标准的患者和对照组，还使用了一份评估RLS严重程度的问卷。对该主题的系统评价和荟萃分析是根据严格的国际标准进行的。
在本报告中，在一项多中心病例对照研究中，巴西MS患者的RLS与MS之间的关联被证实并非偶然。MS患者的RLS症状也比对照组更为严重。文献的系统评价和荟萃分析表明，MS患者出现RLS的几率比对照组高四倍。
尽管解释RLS与MS之间关联的潜在机制仍有待讨论，但这两种神经系统疾病之间存在明确的关联。
