Department of Ophthalmology, Kansai Medical University, Takii Hospital, Osaka, Japan.
Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Jpn J Ophthalmol. 2011 May;55(3):235-240. doi: 10.1007/s10384-011-0010-x. Epub 2011 May 3.
The purpose of this study was to determine the clinical characteristics of age-related macular degeneration (AMD) in patients with diabetic retinopathy (DR).
Retrospective, consecutive case series. Twenty-six eyes of 25 Japanese patients were studied. All patients were diagnosed as having exudative AMD with DR. Patients with no apparent DR, dry AMD, neovascular maculopathy associated with high myopia, and age <50 years were excluded. The clinical characteristics of AMD in patients with DR, e.g., gender, age, stage of DR, and type of AMD were evaluated.
In the 26 eyes, 2 eyes (7.7%) were classified as mild nonproliferative DR (NPDR), 7 (27.0%) with moderate NPDR, 16 (61.5%) with severe NPDR and 1 eye (3.8%) with PDR. Of the 26 eyes with exudative AMD, 21 eyes (80.8%) were classified as neovascular AMD, 4 (15.4%) as polypoidal choroidal vasculopathy and 1 eye (3.8%) as a retinal angiomatous proliferation. Among the eyes with neovascular AMD, 9 eyes (42.9%) were classified as predominantly classic choroidal neovascularization (CNV).
There is a predominance of men, neovascular AMD and predominantly classic CNV in Japanese AMD patients with DR. The exudative AMD in patients with DR may have different clinical characteristics from those without DR.
本研究旨在确定伴有糖尿病视网膜病变（DR）的年龄相关性黄斑变性（AMD）患者的临床特征。
回顾性连续病例系列研究。研究了 25 名日本患者的 26 只眼。所有患者均被诊断为伴有 DR 的渗出性 AMD。排除无明显 DR、干性 AMD、与高度近视相关的新生血管性黄斑病变和年龄<50 岁的患者。评估了伴有 DR 的 AMD 患者的临床特征，如性别、年龄、DR 分期和 AMD 类型。
在 26 只眼中，2 只眼（7.7%）为轻度非增殖性糖尿病视网膜病变（NPDR），7 只眼（27.0%）为中度 NPDR，16 只眼（61.5%）为重度 NPDR，1 只眼（3.8%）为增殖性糖尿病视网膜病变。在 26 只渗出性 AMD 眼中，21 只眼（80.8%）为新生血管性 AMD，4 只眼（15.4%）为息肉状脉络膜血管病变，1 只眼（3.8%）为视网膜血管瘤样增生。在新生血管性 AMD 眼中，9 只眼（42.9%）为主要经典脉络膜新生血管（CNV）。
日本伴有 DR 的 AMD 患者以男性、新生血管性 AMD 和主要经典 CNV 为主。伴有 DR 的渗出性 AMD 的临床特征可能与不伴有 DR 的患者不同。
