金属放射性核素在诊断和治疗放射性药物开发中的应用。
Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals.
机构信息
Applied and Developmental Research Directorate, SAIC-Frederick, National Cancer Institute (NIH/NCI) at Frederick, 1050 Boyles Street, Bldg. 376, Frederick, Maryland, USA.
出版信息
Dalton Trans. 2011 Jun 21;40(23):6112-28. doi: 10.1039/c1dt10379b. Epub 2011 May 3.
Abstract
Metallic radionuclides are the mainstay of both diagnostic and therapeutic radiopharmaceuticals. Therapeutic nuclear medicine is less advanced but has tremendous potential if the radionuclide is accurately targeted. Great interest exists in the field of inorganic chemistry for developing target specific radiopharmaceuticals based on radiometals for non-invasive disease detection and cancer radiotherapy. This perspective will focus on the nuclear properties of a few important radiometals and their recent applications to developing radiopharmaceuticals for imaging and therapy. Other topics for discussion will include imaging techniques, radiotherapy, analytical techniques, and radiation safety. The ultimate goal of this perspective is to introduce inorganic chemists to the field of nuclear medicine and radiopharmaceutical development, where many applications of fundamental inorganic chemistry can be found.
摘要
金属放射性核素是诊断和治疗放射性药物的主要组成部分。治疗核医学虽然相对落后，但如果放射性核素能够准确靶向，那么它具有巨大的潜力。无机化学领域对于开发基于放射性金属的靶向放射性药物以进行非侵入性疾病检测和癌症放射治疗非常感兴趣。本观点将重点介绍几种重要放射性金属的核特性及其最近在开发用于成像和治疗的放射性药物方面的应用。其他讨论主题将包括成像技术、放射治疗、分析技术和辐射安全。本观点的最终目标是向无机化学家介绍核医学和放射性药物开发领域，在这个领域中可以找到基础无机化学的许多应用。
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