Center for Environmental, Genetic, and Nutritional Epidemiology CREAGEN, Department of Public Health Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Nutr Cancer. 2011;63(4):506-13. doi: 10.1080/01635581.2011.539314.
The possibility of an inverse association between vitamin D and risk of cancer and, in particular, of cutaneous malignant melanoma has been suggested, but results of epidemiologic studies are still conflicting. We examined the relation between dietary vitamin D intake and melanoma risk through a population-based case-control study (380 cases, 719 controls) in a northern region of Italy, a country with an average vitamin D intake lower than that in northern Europe or the United States. We assessed average daily intake of vitamin D from foodstuffs using the European Prospective Investigation into Cancer and Nutrition (EPIC) semiquantitative food frequency questionnaire. In this population, levels of vitamin D intake were considerably lower than those observed in recent U.S. studies. We found an inverse relation between dietary vitamin D and melanoma risk in the sample as a whole, in both crude and adjusted analyses. In sex- and age-specific analyses, this association appeared to be stronger among males and among older subjects. These findings suggest that, at the relatively low levels of intake observed in this sample, an inverse relation between dietary vitamin D and risk of cutaneous malignant melanoma may exist.
人们提出维生素 D 与癌症风险（尤其是皮肤恶性黑色素瘤）之间可能存在负相关关系，但流行病学研究的结果仍存在争议。我们通过在意大利北部地区进行的一项基于人群的病例对照研究（380 例病例，719 例对照）来研究饮食维生素 D 摄入与黑色素瘤风险之间的关系，意大利的维生素 D 摄入量平均低于北欧或美国。我们使用欧洲癌症前瞻性调查与营养（EPIC）半定量食物频率问卷评估了从食物中获得的维生素 D 的平均日摄入量。在该人群中，维生素 D 的摄入量明显低于最近在美国进行的研究中观察到的水平。我们发现，在整个样本中，膳食维生素 D 与黑色素瘤风险之间呈负相关，在未调整和调整分析中均如此。在按性别和年龄分层的分析中，这种关联在男性和年龄较大的人群中似乎更强。这些发现表明，在该样本中观察到的相对较低的摄入水平下，饮食维生素 D 与皮肤恶性黑色素瘤风险之间可能存在负相关关系。
