State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, PR China.
Diagn Microbiol Infect Dis. 2012 Aug;73(4):369-71. doi: 10.1016/j.diagmicrobio.2012.04.010. Epub 2012 May 25.
A case of fatal invasion of Scopulariopsis brevicaulis to the bronchus in an acute monocytic leukemia (M(5)) patient is described. This infection leads to mediastinal emphysema, bronchial bleeding, and bronchial obstruction before finally spreading to the entire lung. The patient was initially diagnosed with pulmonary aspergillosis based on clinical signs and morphological examination. However, S. brevicaulis was finally identified by 18S rDNA sequencing. The patient failed lipid amphotericin B therapy and voriconazole plus caspofungin combination therapy. To the best of our knowledge, this is the first report on S. brevicaulis affecting the bronchus and resulting in a fatal prognosis in an M(5) patient.
本文描述了一例由短帚霉（Scopulariopsis brevicaulis）引起的支气管侵袭，患者患有急性单核细胞白血病（M5）。该感染导致纵隔气肿、支气管出血和支气管阻塞，最终蔓延至整个肺部。该患者最初根据临床症状和形态学检查诊断为肺曲霉病。然而，最终通过 18S rDNA 测序鉴定为短帚霉。该患者对脂质两性霉素 B 治疗和伏立康唑加卡泊芬净联合治疗无效。据我们所知，这是首例报道短帚霉影响支气管并导致 M5 患者预后不良的病例。
