Department of Biomedical Sciences, School of Medicine, Madda Walabu University, Robe, Ethiopia.
Department of Biochemistry, School of Biomedical Sciences, Jimma University, Jimma, Ethiopia.
PLoS One. 2024 Nov 4;19(11):e0310047. doi: 10.1371/journal.pone.0310047. eCollection 2024.
About half of the world's populations are infected with Helicobacter pylori, which may create atherogenic lipid profiles and contribute to atherosclerosis and related cardiovascular disease. Furthermore, it has been connected to hematological symptoms like anemia. Even though the high prevalence of H.pylori and its associated complications, including cardiovascular disease and anemia, in Ethiopia, there is little data regarding the risk factors associated with H.pylori infection, such as hematologic parameters, electrolyte imbalances, and lipid profiles.
A comparative cross-sectional study design with a consecutive sampling technique was employed at Jimma Medical Center among 108 dyspeptic patients. Five (5) ml of blood samples were collected from each participant, and serum was extracted and analyzed using a COBAS 6000 core for the lipid and electrolyte, and whole blood was used with a SYSMEX XN 550 to determine hematological parameters. Data were entered in to Epi-data version 4.6 and exported to SPSS version 25 for analysis. Simple descriptive statistics and chi-square test were used to present the socio-demographic characteristics of the study subjects. Student t-test was used for data comparison and p-value < 0.05 was considered statistically significant.
H.pylori infected patients had significantly decreased levels of red blood cell count (p = 0.002), hemoglobin (p = 0.012), mean corpuscular hemoglobin concentration (p < 0.001), platelet count (p = 0.001), and sodium level (p = 0.006) when compared to the uninfected group. However, total cholesterol (p = 0.001), and low density lipoprotein (p = 0.021) were increased in H.pylori infected patients when compared to the uninfected group.
This study revealed that H.pylori infection can cause derangements of hematologic parameters, electrolyte imbalances, and alterations of lipid parameters which considered as risk factors for anemia and cardiovascular diseases.
全球约有一半的人口感染了幽门螺杆菌，这可能导致动脉粥样硬化和相关心血管疾病的致动脉粥样硬化脂质谱，并与贫血等血液学症状有关。尽管幽门螺杆菌在埃塞俄比亚的高患病率及其相关并发症，包括心血管疾病和贫血，但其相关危险因素，如血液学参数、电解质失衡和脂质谱，数据很少。
采用吉姆马医疗中心的 108 例消化不良患者的横断面比较研究设计，采用连续抽样技术。从每个参与者中采集 5（5）毫升血样，使用 COBAS 6000 核心提取和分析血清以检测脂质和电解质，使用 SYSMEX XN 550 检测全血以确定血液学参数。数据输入 Epi-data 版本 4.6 并导出到 SPSS 版本 25 进行分析。使用简单描述性统计和卡方检验来呈现研究对象的社会人口统计学特征。使用学生 t 检验进行数据比较，p 值<0.05 被认为具有统计学意义。
与未感染组相比，幽门螺杆菌感染患者的红细胞计数（p = 0.002）、血红蛋白（p = 0.012）、平均红细胞血红蛋白浓度（p < 0.001）、血小板计数（p = 0.001）和钠水平（p = 0.006）显著降低。然而，与未感染组相比，感染组的总胆固醇（p = 0.001）和低密度脂蛋白（p = 0.021）升高。
本研究表明，幽门螺杆菌感染可导致血液学参数、电解质失衡和脂质参数改变，这些改变被认为是贫血和心血管疾病的危险因素。
