Departments of Radiology and Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
Nat Rev Cancer. 2011 Apr;11(4):237-8. doi: 10.1038/nrc3036.
We propose that the drivers of carcinogenesis lie more in the adaptive changes that are enabled by local or systemic alterations of tissue architecture than in the genetic changes observed in cancer cells. A full understanding of cancer biology and therapy through a cataloguing of the cancer genome is unlikely unless it is integrated into an evolutionary and ecological context.
我们认为,致癌的驱动因素更多地在于组织架构的局部或系统性改变所带来的适应性变化,而不是癌细胞中观察到的遗传变化。除非将其整合到进化和生态背景中,否则通过对癌症基因组进行编目来全面了解癌症生物学和治疗方法是不太可能的。