Departments of Radiology and Integrated Mathematical Oncology, Moffitt Cancer Center, USA.
Nat Rev Cancer. 2010 Aug;10(8):526-7. doi: 10.1038/nrc2892.
Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.
多细胞生物在繁殖之前必须进化出抑制癌症形成的机制，我们提出正常上皮组织的结构就是这样一种策略。了解进化过程中宿主抑制癌症的机制对于确定癌症发生的第一步和制定合理的癌症预防策略至关重要。
