Department of Obstetrics and Gynecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Fertil Steril. 2011 Jul;96(1):230-5. doi: 10.1016/j.fertnstert.2011.04.003. Epub 2011 May 5.
To assess the relationship between antimüllerian hormone (AMH) and parameters related to polycystic ovary syndrome (PCOS).
Prospective study.
Academic tertiary care center.
PATIENT(S): A total of 290 women.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Parameters related to insulin resistance and metabolic syndrome.
RESULT(S): Women with polycystic ovary morphology had significantly higher AMH levels than women in the control group. The prevalence of PCOS increased from 21% in the low-AMH (<4 ng/mL) group to 37% in the moderate-AMH (4-11 ng/mL) group and 80% in the high-AMH (>11 ng/mL) group. However, significant differences in insulin resistance parameters were not observed among groups. The results of the correlation analysis revealed that AMH levels were positively correlated with LH, total T, A, and total cholesterol content; however, AMH levels were negatively correlated with age, body mass index, and the number of menstrual cycles per year. AMH levels were not correlated with insulin resistance parameters.
CONCLUSION(S): Elevated serum AMH levels increase the risk of PCOS but do not affect the risk of insulin resistance or metabolic syndrome.
评估抗缪勒管激素（AMH）与多囊卵巢综合征（PCOS）相关参数之间的关系。
前瞻性研究。
学术三级保健中心。
共计 290 名女性。
无。
与胰岛素抵抗和代谢综合征相关的参数。
多囊卵巢形态的女性 AMH 水平明显高于对照组。PCOS 的患病率从低 AMH（<4ng/mL）组的 21%上升至中 AMH（4-11ng/mL）组的 37%和高 AMH（>11ng/mL）组的 80%。然而，各组之间的胰岛素抵抗参数无显著差异。相关分析结果表明，AMH 水平与 LH、总 T、A 和总胆固醇含量呈正相关；然而，AMH 水平与年龄、体重指数和每年月经周期数呈负相关。AMH 水平与胰岛素抵抗参数无关。
血清 AMH 水平升高会增加 PCOS 的风险，但不会影响胰岛素抵抗或代谢综合征的风险。
