Key Lab of Chemical Safety and Health, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing, 100050, China.
Environ Int. 2012 Jul;42:67-71. doi: 10.1016/j.envint.2011.04.007. Epub 2011 May 6.
Diet is an important source of perfluorinated compound (PFC) exposure and seafood is an important diet component for coastal populations. Therefore, it is necessary to monitor the concentrations of PFCs in seafood. In this study, we measured thirteen PFCs in 47 fatty fish and 45 shellfish samples collected from six coastal provinces in China (Liaoning, Shandong, Jiangsu, Zhejiang, Fujian, and Guangdong), using an ultra-performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). Perfluorooctanesulfonate (PFOS) was the dominant PFC in fatty fish which accounted for 38% of total PFCs, whereas perfluoroctanoic acid (PFOA) was the predominant PFC in shellfish. Concentrations of PFOS were ranged from less than 1.4 to 1627 pg/g wet weight in fatty fish, with the highest concentration in red drum from Jiangsu. Concentrations of PFOA in shellfish ranged from less than 5.4 to 7543 pg/g wet weight, with the maximum concentration found in briny clam also from Jiangsu. Compared with other studies, the PFC levels in seafood collected from our studied areas are relatively low. The estimated dietary intakes (EDI, pg/kg body weight /day) of PFOA, PFOS and total PFCs for the reference man (63 kg body weight) were calculated by multiplying the mean concentrations (pg/g wet weight) of PFOA, PFOS and total PFCs in six coastal provinces with the daily consumption data (g/day) from the fourth Chinese total diet study carried out in 2007. The highest EDI of PFOS and PFOA were found to be 694 pg/kg body weight/day and 914 pg/kg body weight/day in Guangdong and Jiangsu, respectively. However, the highest EDI of total PFCs was found in Fujian at 2513 pg/kg body weight/day. The EDI from seafood is much lower than the tolerable daily intake (TDI) recommended by the European Food Safety Authority in 2008 indicating low health risk of PFC exposure via eating seafood among the coastal populations in China.
饮食是全氟化合物 (PFC) 暴露的一个重要来源，而海鲜是沿海地区人群饮食的重要组成部分。因此，有必要监测海鲜中的 PFC 浓度。在这项研究中，我们使用超高效液相色谱-串联质谱法 (UPLC-MS/MS) 测量了来自中国六个沿海省份（辽宁、山东、江苏、浙江、福建和广东）的 47 种高脂肪鱼类和 45 种贝类样本中的 13 种 PFC。全氟辛烷磺酸 (PFOS) 是高脂肪鱼类中主要的 PFC，占总 PFC 的 38%，而全氟辛酸 (PFOA) 是贝类中的主要 PFC。高脂肪鱼类中 PFOS 的浓度范围为 1.4 至 1627 pg/g 湿重，江苏红鲷鱼中的浓度最高。贝类中 PFOA 的浓度范围为 5.4 至 7543 pg/g 湿重，江苏文蛤中的浓度最高。与其他研究相比，我们研究区域采集的海鲜中的 PFC 水平相对较低。根据 2007 年进行的第四次中国总膳食研究中获得的每日消费量数据 (g/day)，用中国沿海六个省份的 PFOA、PFOS 和总 PFC 的平均浓度 (pg/g 湿重) 乘以参考人 (63 公斤体重) 的估计膳食摄入量 (EDI，pg/kg 体重/天)。结果发现，广东和江苏的 PFOS 和 PFOA 的最高 EDI 分别为 694 pg/kg 体重/天和 914 pg/kg 体重/天。然而，福建的总 PFCs 的最高 EDI 为 2513 pg/kg 体重/天。来自海鲜的 EDI 远低于欧洲食品安全局 2008 年建议的可耐受每日摄入量 (TDI)，这表明中国沿海地区人群通过食用海鲜暴露于 PFC 风险较低。
