比较促肾上腺皮质激素片段 4-10（ACTH(4-10)）和 [D-Phe7]ACTH(4-10) 对豚鼠自发性眼球震颤代偿的影响。

Comparison of the effects of adrenocorticotropic hormone fragment 4-10 (ACTH(4-10)) and [D-Phe7]ACTH(4-10) on the compensation of spontaneous nystagmus in guinea pig.

机构信息

Department of Psychology and the Neuroscience Research Centre, University of Otago, Dunedin (New Zealand).

出版信息

Restor Neurol Neurosci. 1992 Jan 1;3(6):345-8. doi: 10.3233/RNN-1992-3607.

DOI:10.3233/RNN-1992-3607

Abstract

Following unilateral labyrinthectomy (UL), spontaneous nystagmus (SN) was measured in guinea pigs which received i.m. injections of 100 or 400 µg/kg ACTH(4-10) or 800 µg/kg [D-Phe7]ACTH(4-10), every 4 h for 48 h post-UL. The results were compared to those from a previous study, conducted under identical conditions, in which guinea pigs received similar injections of 200 µg/kg ACTH(4-10) or 0.1 ml/kg saline. ACTH(4-10) significantly accelerated the rate of compensation of SN at 100, 200, and 400 µg/kg doses, although the average effects were larger for the 200 µg/kg condition. [D-Phe7]ACTH(4-10) significantly increased the frequency of SN following UL compared to saline-treated animals; however, it also accelerated the rate of SN compensation. These results indicate that the acceleration of SN compensation in guinea pig by ACTH(4-10) follows an inverted U-shaped dose-response curve and that [D-Phe7]ACTH(4-10) increases the frequency of SN.

摘要

单侧迷路切除（UL）后，给豚鼠肌内注射 100 或 400μg/kg ACTH(4-10)或 800μg/kg [D-Phe7]ACTH(4-10)，每 4 小时一次，共 48 小时，测量其自发眼震（SN）。将结果与之前在相同条件下进行的一项研究进行比较，该研究中，豚鼠接受类似的 200μg/kg ACTH(4-10)或 0.1ml/kg 生理盐水注射。ACTH(4-10)在 100、200 和 400μg/kg 剂量下显著加速 SN 的代偿速度，尽管在 200μg/kg 条件下的平均效果更大。[D-Phe7]ACTH(4-10)与生理盐水处理的动物相比，显著增加 UL 后 SN 的频率；然而，它也加速了 SN 的代偿速度。这些结果表明，ACTH(4-10)在豚鼠中加速 SN 代偿遵循倒 U 形剂量反应曲线，并且 [D-Phe7]ACTH(4-10)增加了 SN 的频率。