Department of Hand Surgery, Lund University, General Hospital, Malmö (Sweden).
Restor Neurol Neurosci. 1993 Jan 1;5(3):197-204. doi: 10.3233/RNN-1993-5304.
Matrix formation within silicone tubes of different geometries implanted between the stumps of the transected rat sciatic nerve was studied. A matrix, composed of longitudinally oriented fibrin strands containing fibronectin, was formed within one day. The matrix then increased in size. The matrix contained macrophages and other inflammatory cells. Matrix size could be increased if the diameter of the tube was increased or if holes were made in the implanted tube. In contrast, matrix diameter decreased if the tube length was increased or if circulation was compromised in the inserts. The results suggest that the size, orientation and cellular components of the matrix have profound effects on the regenerative response of the transected nerve.
研究了不同几何形状的硅胶管在切断的大鼠坐骨神经残端之间植入时内部的基质形成情况。一天内，形成了一种由含有纤维连接蛋白的纵向纤维蛋白丝组成的基质，随后基质增大。该基质含有巨噬细胞和其他炎症细胞。如果增加管的直径或在植入管上打孔，则可以增加基质的大小。相反，如果增加管的长度或插入物中的循环受到损害，则基质直径会减小。结果表明，基质的大小、取向和细胞成分对切断神经的再生反应有深远影响。
