Musabak Ugur, Kilciler Guldem, Uygun Ahmet, Kantarcıoglu Murat, Polat Zulfukar, Sagkan Rahsan I, Bagci Sait
Department of Immunology, Gulhane Military Medical Academy and School of Medicine, 06018 Etlik, Ankara, Turkey.
Open Rheumatol J. 2011 Feb 4;5:13-7. doi: 10.2174/1874312901105010013.
The pineal hormone melatonin plays a crucial role in immunomodulation, mainly by effecting T cells. The aims of the present study were to compare the melatonin levels in patients with Familial Mediterranean Fever (FMF) and healthy controls and to find out if it associates with interferon(IFN)γ and interleukin(IL)-10.
Twenty five patients with FMF and 16 healthy donors were enrolled into the study. Melatonin, IFN γ and IL-10 measurements were assayed by using enzyme immunoassay (EIA) method.
Serum melatonin levels at 03.30 am in both patients during attack-free phase and healthy controls were significantly higher than those levels of corresponding groups measured at 10.00 am. The melatonin levels at 03.30 and 10.00 am in patients during attack-free phase were higher than those levels measured in healthy controls at the same time points. IFNγ and IL-10 did not show any day and night rhythm in both patients and healthy controls. In addition, there was no association among day and night levels of melatonin, IFNγ and IL-10.
We conclude that melatonin may play a role in FMF pathogenesis. However, its modulatory effect on immune response most likely does not depend on T cells. Further comprehensive studies should be performed in order to reveal the role of melatonin in the pathogenesis of this disease.
松果体激素褪黑素在免疫调节中起关键作用，主要通过影响T细胞发挥作用。本研究的目的是比较家族性地中海热（FMF）患者和健康对照者的褪黑素水平，并探究其是否与干扰素（IFN）γ和白细胞介素（IL）-10相关。
25例FMF患者和16名健康捐赠者纳入本研究。采用酶免疫分析（EIA）法检测褪黑素、IFNγ和IL-10水平。
无发作期患者和健康对照者凌晨03:30的血清褪黑素水平均显著高于上午10:00相应组别的水平。无发作期患者凌晨03:30和上午10:00的褪黑素水平高于同一时间点健康对照者的水平。患者和健康对照者的IFNγ和IL-10均未表现出昼夜节律。此外，褪黑素、IFNγ和IL-10的昼夜水平之间无关联。
我们得出结论，褪黑素可能在FMF发病机制中起作用。然而，其对免疫反应的调节作用很可能不依赖于T细胞。为揭示褪黑素在该疾病发病机制中的作用，应进行进一步的全面研究。
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