Komarov Sergey A, Wu Heyu, Keesing Daniel B, O'Sullivan Joseph A, Tai Yuan-Chuan
Radiology Department, Washington University in St. Louis, St. Louis, MO 63130 USA.
IEEE Trans Nucl Sci. 2010;57(3):1045-1051. doi: 10.1109/TNS.2010.2046754.
The integration of a high resolution PET insert into a conventional PET system can significantly improve the resolution and the contrast of its images within a reduced imaging field of view. For the rest of the scanner imaging field of view, the insert is a highly attenuating and scattering media. In order to use all available coincidence events (including coincidences between 2 detectors in the original scanner, namely the scanner-scanner coincidences), appropriate scatter and attenuation corrections have to be implemented. In this work, we conducted a series of Monte Carlo simulations to estimate the composition of the scattering background and the importance of the scatter correction. We implemented and tested the Single Scatter Simulation (SSS) algorithm for a hypothetical system and show good agreement between the estimated scatter using SSS and Monte Carlo simulated scatter contribution. We further applied the SSS to estimate scatter contribution from an existing prototype PET insert for a clinical PET/CT scanner. The results demonstrated the applicability of SSS to estimate the scatter contribution within a clinical PET/CT system even when there is a high resolution half ring PET insert device in its imaging field of view.
将高分辨率正电子发射断层扫描(PET)插入件集成到传统PET系统中,可以在缩小的成像视野内显著提高其图像的分辨率和对比度。对于扫描仪其余的成像视野,该插入件是一种高衰减和散射介质。为了利用所有可用的符合事件(包括原始扫描仪中两个探测器之间的符合事件,即扫描仪 - 扫描仪符合事件),必须实施适当的散射和衰减校正。在这项工作中,我们进行了一系列蒙特卡罗模拟,以估计散射本底的组成和散射校正的重要性。我们针对一个假设系统实现并测试了单散射模拟(SSS)算法,结果表明使用SSS估计的散射与蒙特卡罗模拟的散射贡献之间具有良好的一致性。我们进一步应用SSS来估计临床PET/CT扫描仪现有原型PET插入件的散射贡献。结果表明,即使在临床PET/CT系统的成像视野中有高分辨率半环PET插入装置时,SSS也适用于估计散射贡献。