合成一种新型荧光小分子探针及其在体内脂质成像中的应用。

Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging.

机构信息

Bioorganic Division, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.

出版信息

Chem Commun (Camb). 2011 Jul 14;47(26):7500-2. doi: 10.1039/c1cc11253h. Epub 2011 May 9.

Abstract

A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.

摘要

一种新的用于体内脂质成像的小分子探针，LipidGreen（化合物 5）被开发出来。LipidGreen 可以对 3T3L1 细胞系中的脂滴和斑马鱼体内的脂肪沉积物进行染色，在高达 100 μM 的浓度下没有明显的毒性。LipidGreen 作为一种用于脂肪调节的药物筛选平台在活体斑马鱼中的应用也得到了证明。