Animal Core, Shantou University Medical College, Shantou 515041, China.
J Neuroimmune Pharmacol. 2011 Sep;6(3):323-9. doi: 10.1007/s11481-011-9280-9. Epub 2011 May 10.
Recently, an interaction between neurodegenerative processes and the innate and adaptive immune responses has been increasingly recognized. Activation of microglia, infiltration of peripheral T lymphocytes, and T-cell interaction with microglia may strongly affect the progression of Parkinson's disease (PD) both in patients and in animal models of the disease. Here, we summarize the current knowledge regarding the role of microglia in the progression of PD. The plasticity of the microglial response is also discussed in the context of PD. In addition, we also focus on the influence of several peripheral T-cell subsets on PD progression as well as on possible pathways by which they might act. This review should help increase our understanding of the effects of innate and adaptive immune cells in the pathogenesis of PD.
最近，人们越来越认识到神经退行性过程与固有和适应性免疫反应之间的相互作用。小胶质细胞的激活、外周 T 淋巴细胞的浸润以及 T 细胞与小胶质细胞的相互作用可能强烈影响帕金森病（PD）患者和疾病动物模型的疾病进展。在这里，我们总结了目前关于小胶质细胞在 PD 进展中的作用的知识。还讨论了小胶质细胞反应的可塑性。此外，我们还重点关注了几种外周 T 细胞亚群对 PD 进展的影响以及它们可能作用的途径。这篇综述应该有助于我们更好地理解固有和适应性免疫细胞在 PD 发病机制中的作用。
