Institute of Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, 97078, Würzburg, Germany.
J Neural Transm (Vienna). 2013 Jan;120(1):75-81. doi: 10.1007/s00702-012-0842-7. Epub 2012 Jun 15.
Innate and adaptive immune responses in neurodegenerative diseases have become recently a focus of research and discussions. Parkinson's disease (PD) is a neurodegenerative disorder without known etiopathogenesis. The past decade has generated evidence for an involvement of the immune system in PD pathogenesis. Both inflammatory and autoimmune mechanisms have been recognized and studies have emphasized the role of activated microglia and T-cell infiltration. In this short review, we focus on dendritic cells, on their role in initiation of autoimmune responses, we discuss aspects of neuroinflammation and autoimmunity in PD, and we report new evidence for the involvement of neuromelanin in these processes.
先天和适应性免疫反应在神经退行性疾病中已成为研究和讨论的焦点。帕金森病（PD）是一种病因不明的神经退行性疾病。过去十年的研究为免疫系统参与 PD 发病机制提供了证据。炎症和自身免疫机制都已被认识到，研究强调了活化的小胶质细胞和 T 细胞浸润的作用。在这篇简短的综述中，我们重点讨论树突状细胞在自身免疫反应启动中的作用，讨论 PD 中的神经炎症和自身免疫的各个方面，并报告神经黑色素参与这些过程的新证据。
