（±）- 表贝壳杉烷碱 A 的全合成。
Total synthesis of (±)-aspidophylline A.
机构信息
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
出版信息
J Am Chem Soc. 2011 Jun 15;133(23):8877-9. doi: 10.1021/ja203227q. Epub 2011 May 18.
We report the total synthesis of (±)-aspidophylline A, one of many complex furoindoline-containing alkaloids that has not been synthesized previously. Our route features a number of key transformations, including a Heck cyclization to assemble the [3.3.1]-bicyclic scaffold as well as a late-stage interrupted Fischer indolization to install the furoindoline and construct the natural product's pentacyclic framework.
我们报告了（±）-aspidophylline A 的全合成，（±）-aspidophylline A 是许多以前尚未合成的含呋喃吲哚生物碱之一。我们的路线具有许多关键的转化，包括 Heck 环化以组装[3.3.1]-双环支架，以及晚期中断的 Fischer 吲哚化以安装呋喃吲哚并构建天然产物的五环骨架。
Zotero 插件