吲哚生物碱（±）-和（+）-甲基 N-去甲氧基香佛他嗪的全合成。
Total synthesis of the indole alkaloid (±)- and (+)-methyl N-decarbomethoxychanofruticosinate.
机构信息
State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032 (China).
出版信息
Angew Chem Int Ed Engl. 2013 Dec 2;52(49):12988-91. doi: 10.1002/anie.201307788. Epub 2013 Nov 20.
PMID:24258849
Abstract
All caged up: The first total synthesis of N-decarbomethoxychanofruticosinate is achieved by using a SmI2 -mediated intramolecular Reformatsky-like reaction to create the seven-membered ring, and an intramolecular oxidative coupling to install the caged and strained ring system.
摘要
笼状结构全合成
首次通过 SmI2 介导的分子内类似 Reformatsky 反应构建七元环，并通过分子内氧化偶联构建笼状和张力环系，实现了 N-去甲氧基香豆佛土辛酸盐的全合成。
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