Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, New York 10031, USA.
J Am Chem Soc. 2011 Jun 8;133(22):8478-81. doi: 10.1021/ja202769t. Epub 2011 May 12.
We report a Ni-catalyzed process for the cross-coupling of tertiary alkyl nucleophiles and aryl bromides. This process is extremely general for a wide range of electrophiles and generally occurs with a ratio of retention to isomerization >30:1. The same procedure also accommodates the use of aryl triflates, vinyl chlorides, and vinyl bromides as the electrophilic component.
我们报告了一种镍催化的三级烷基亲核试剂与芳基溴化物的交叉偶联反应。该反应对各种亲电试剂具有极好的通用性,并且通常保持对异构体的比例大于 30:1。同样的方法也可以适用于芳基三氟甲磺酸酯、氯代乙烯和溴代乙烯作为亲电试剂。