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改性钛表面改变成骨分化：基于微阵列的人骨髓间充质细胞对商用钛表面反应的比较分析

Modified titanium surfaces alter osteogenic differentiation: a comparative microarray-based analysis of human mesenchymal cell response to commercial titanium surfaces.

作者信息

Mamalis Anastasios, Silvestros Spyridon

出版信息

J Oral Implantol. 2013 Oct;39(5):591-601. doi: 10.1563/AAID-JOI-D-10-00209. Epub 2011 May 9.

DOI:10.1563/AAID-JOI-D-10-00209
PMID:21554083
Abstract

The differential effects of dual-acid etched (Osseotite), hydroxyapatite coated (HA) and sand-blasted/acid-etched (SLA) titanium surfaces on human bone marrow-derived mesenchymal cells (hMSCs) were investigated. Proliferation was significantly promoted on the SLA surfaces. 16 genes were significantly upregulated when hMSCs were cultured on the Osseotite and the HA surfaces and 15 genes on the SLA surfaces. Upregulated genes control cell differentiation, signal transduction, cell cycle regulation, angiogenesis, cell adhesion, and extracellular matrix and bone formation.

摘要

研究了双酸蚀刻（Osseotite）、羟基磷灰石涂层（HA）和喷砂/酸蚀刻（SLA）钛表面对人骨髓间充质细胞（hMSCs）的不同影响。SLA表面上细胞增殖显著增强。当hMSCs在Osseotite和HA表面培养时，有16个基因显著上调，在SLA表面有15个基因显著上调。上调的基因控制细胞分化、信号转导、细胞周期调控、血管生成、细胞黏附以及细胞外基质和骨形成。

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