Babalola O E, Amoni S S, Samaila E, Thaker U, Darougar S
Guinness Ophthalmic Unit, Ahmadu Bello University Teaching Hospital, Institute of Health, Kaduna, Nigeria.
Br J Ophthalmol. 1990 Feb;74(2):89-92. doi: 10.1136/bjo.74.2.89.
Clinical studies were carried out on two groups of patients with acute haemorrhagic conjunctivitis (AHC) during an epidemic in 1985 in Northern Nigeria. Group 1 consisted of 99 students attending a girls' boarding school, group 2 of 200 patients selected randomly from 1000 examined at the local clinic. Moderate to severe hyperaemia and papillary responses were present in the palpebral conjunctiva of all patients, and 234 (66%) had subconjunctival haemorrhages. Transient superficial punctate keratitis was noted in over 60% of patients. A transient flare suggestive of a low grade iritis was seen in five patients. No neurological disorders were noted. Serological studies were carried out on patients from group 2. Fifteen paired and 20 single serum samples were titrated against adenovirus type 4 (Ad-4) and enterovirus type 70 (EV-70). Two pairs of sera showed a 4-fold rise in antibody levels to EV-70, whereas the antibody titres to EV-70 in the rest of the sera ranged from 1:20 (no antibody) to 1:160. None of the paired serum samples showed a 4-fold rise in antibody levels to adenovirus. The results of clinical studies and serological findings support EV-70 as a probable cause of AHC in Nigeria.
1985年在尼日利亚北部疫情期间，对两组急性出血性结膜炎（AHC）患者进行了临床研究。第一组由99名就读于女子寄宿学校的学生组成，第二组由从当地诊所检查的1000名患者中随机选取的200名患者组成。所有患者睑结膜均有中度至重度充血和乳头反应，234例（66%）有结膜下出血。60%以上的患者出现短暂性浅层点状角膜炎。5例患者出现提示轻度虹膜炎的短暂性闪光。未发现神经障碍。对第二组患者进行了血清学研究。15对和20份单份血清样本针对4型腺病毒（Ad-4）和70型肠道病毒（EV-70）进行了滴定。两对血清显示针对EV-70的抗体水平有4倍升高，而其余血清中针对EV-70的抗体滴度范围为1:20（无抗体）至1:160。没有一对血清样本显示针对腺病毒的抗体水平有4倍升高。临床研究结果和血清学发现支持EV-70可能是尼日利亚AHC的病因。
