Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
J Gastroenterol. 2011 Jul;46(7):894-905. doi: 10.1007/s00535-011-0410-1. Epub 2011 May 10.
Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use.
Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for more than 3 months) plus omeprazole 20 mg daily and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial. We assigned the patients to receive probiotic treatment with Lactobacillus casei for 3 months (L. casei group) or not receive the probiotic (control group). Patients underwent capsule endoscopy (CE) before and after treatment.
Twenty-five patients, including 13 in the L. casei group and 12 in the control group, underwent the full analysis. Significant decreases in the number of mucosal breaks and the CE score were observed at the 3-month evaluation in the L. casei group as compared with the results in the control group (P = 0.039). The change from the baseline in the median number of mucosal breaks in the L. casei group was -2, as compared with 0.5 in the control group. The change from the baseline in the median CE score in the L. casei group was -228 compared with -4 in the control group (P = 0.026).
Co-administration of L. casei is effective for the treatment of aspirin-associated small bowel injury.
很少有研究调查预防阿司匹林引起的小肠损伤的措施。我们的目的是评估益生菌治疗对慢性低剂量阿司匹林使用引起的小肠损伤的影响。
35 名每天服用低剂量肠溶阿司匹林 100mg（超过 3 个月）加奥美拉唑 20mg 并被诊断为不明原因缺铁性贫血的患者参加了这项前瞻性随机对照试验。我们将患者分为接受鼠李糖乳杆菌治疗 3 个月（L. casei 组）或不接受益生菌治疗（对照组）。患者在治疗前后接受胶囊内镜（CE）检查。
25 名患者，包括 L. casei 组 13 名和对照组 12 名，完成了全分析。与对照组相比，L. casei 组在 3 个月评估时黏膜破裂数量和 CE 评分显著下降（P=0.039）。L. casei 组的中位数黏膜破裂数量从基线的变化为-2，而对照组为 0.5。L. casei 组的中位数 CE 评分从基线的变化为-228，而对照组为-4（P=0.026）。
L. casei 的联合应用可有效治疗阿司匹林相关的小肠损伤。
