Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China.
J Sci Food Agric. 2010 Jul;90(9):1485-91. doi: 10.1002/jsfa.3972.
Nutritional factors play an important role in skeletal development during growth. However, the absorption rates of many bone-related minerals are relatively low from traditional diets, especially for people in Asia and Africa. In the present study, the effect of marine collagen peptides (MCP) derived from chum salmon (Oncorhynchus keta) skin on the development of femurs in growing rats of both sexes was investigated.
MCP supplementation could increase the size, mineral density, dry weight, ash weight, content of most minerals and both stiffness and toughness of femurs in male growing rats. However, such effects were milder in female rats. The reported increase in mineral density was likely to be related to increased osteoblast activity rather than a decreased rate of bone resorption, as an increase in serum osteocalcin and bone-specific alkaline phosphatase content was observed, but no significant difference in serum N-terminal telopeptide of type I collagen compared with control was found.
MCP supplementation could promote the development of long bones in growing male rats.
营养因素在生长过程中的骨骼发育中起着重要作用。然而，传统饮食中许多与骨骼相关的矿物质的吸收率相对较低，特别是亚洲和非洲的人群。本研究探讨了源自大麻哈鱼（Oncorhynchus keta）皮的海洋胶原蛋白肽（MCP）对雌雄生长大鼠股骨发育的影响。
MCP 补充可增加雄性生长大鼠股骨的大小、矿物质密度、干重、灰分重量、大多数矿物质含量以及股骨的刚度和韧性。然而，这种作用在雌性大鼠中较为温和。报道的矿物质密度增加可能与成骨细胞活性的增加有关，而不是骨吸收率的降低，因为血清骨钙素和骨特异性碱性磷酸酶含量增加，但与对照组相比，血清 I 型胶原 N 末端肽并无显著差异。
MCP 补充可促进雄性生长大鼠长骨的发育。
