Scatliff Candice E, Koski Kristine G, Scott Marilyn E
School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste-Anne-de-Bellevue, Quebec H9X 3V9, Canada.
Food Nutr Bull. 2011 Mar;32(1):54-9. doi: 10.1177/156482651103200106.
The role of gastrointestinal infection as a factor determining vitamin B12 status in populations with low intake of animal-source foods is unclear.
To determine dietary adequacy and serum concentrations of vitamin B12 in an extremely impoverished indigenous population of Panamanian children aged 12 to 60 months, and to identify predictors of both dietary and serum vitamin B12.
A previous community-based survey provided the usual dietary intake and personal, household, and infection (Ascaris and diarrheal disease) information for 209 weaned children. Serum vitamin B12 was assayed using electrochemiluminescence for 65 of these children. Children with adequate or inadequate dietary vitamin B12 intake were compared, and predictors of dietary and serum vitamin B12 were identified using stepwise regression analyses of one index child per household.
Dietary vitamin B12 intake was inadequate in 43% of children; these children were poorer, had less frequent diarrhea, and obtained a higher percentage of their energy from carbohydrate than children with adequate intake. Energy intake positively predicted dietary vitamin B12 intake. In contrast, serum vitamin B12 concentrations were normal in all but 3% of the children. Serum vitamin B12 was positively associated with weekly servings of fruit, corn-based food, and name (a traditional starchy food), but not with animal-source foods. Finally, serum vitamin B12 was not associated with Ascaris intensity but was lowered with increasing frequency of diarrhea.
Although inadequate dietary intake of vitamin B12 was common, most serum values were normal. Nevertheless, diarrheal disease emerged as a negative predictor of serum vitamin B12 concentration.
在动物源食物摄入量低的人群中，胃肠道感染作为决定维生素B12状态的一个因素，其作用尚不清楚。
确定巴拿马12至60个月大极度贫困的土著儿童群体中维生素B12的膳食充足性和血清浓度，并确定膳食和血清维生素B12的预测因素。
之前一项基于社区的调查提供了209名断奶儿童的通常膳食摄入量以及个人、家庭和感染（蛔虫和腹泻病）信息。对其中65名儿童使用电化学发光法检测血清维生素B12。比较膳食维生素B12摄入量充足或不足的儿童，并通过对每户一名指标儿童进行逐步回归分析，确定膳食和血清维生素B12的预测因素。
43%的儿童膳食维生素B12摄入量不足；这些儿童较贫困，腹泻频率较低，与摄入量充足的儿童相比，其能量中碳水化合物所占百分比更高。能量摄入量可正向预测膳食维生素B12摄入量。相比之下，除3%的儿童外，其他所有儿童的血清维生素B12浓度均正常。血清维生素B12与每周水果、玉米类食物和一种传统淀粉类食物（名为“name”）的食用量呈正相关，但与动物源食物无关。最后，血清维生素B12与蛔虫感染强度无关，但随着腹泻频率增加而降低。
尽管膳食维生素B12摄入量不足很常见，但大多数血清值正常。然而，腹泻病是血清维生素B12浓度的一个负向预测因素。
