Herrán Oscar F, Ward Julia B, Villamor Eduardo
1School of Nutrition and Dietetics,Faculty of Health,Industrial University of Santander,Carrera 32 No. 29-31,Office 304,Bucaramanga,Colombia.
2Department of Epidemiology,University of Michigan School of Public Health,Ann Arbor,MI,USA.
Public Health Nutr. 2015 Apr;18(5):836-43. doi: 10.1017/S1368980014001141. Epub 2014 Jun 27.
Vitamin B12 deficiency is associated with many adverse health outcomes and is highly prevalent worldwide. The present study assesses the prevalence of vitamin B12 deficiency and marginal deficiency in Colombian children and women and examines the sociodemographic correlates of serum vitamin B12 concentrations in these groups.
Cross-sectional, nationally representative survey.
Colombia.
Children <18 years old (n 7243), pregnant women (n 1781), and non-pregnant women 18-49 years old (n 499).
The overall prevalence of vitamin B12 deficiency (serum vitamin B12<148 pmol/l) and marginal deficiency (serum vitamin B12=148-221 pmol/l) was, respectively, 6.6 % (95 % CI 5.2%, 8.3%) and 22.5% (95% CI 21.1%, 23.9%). Pregnant women had the highest prevalence of deficiency (18.9 %; 95 % CI 16.6 %, 21.5 %) compared with non-pregnant adult women (18.5%; 95% CI 4.4%, 53.1%) and children (2.8 %; 95 % CI 2.3 % %, 3.3 %). In multivariable analyses among children, mean serum vitamin B12 was positively associated with female sex (12 pmol/l higher compared with males; P=0.004), secondary or higher education of the household head (12 pmol/l higher compared with primary or less; P=0.009) and food security (21 pmol/l higher compared with severe food insecurity; P=0.003). In multivariable analyses among pregnant women, mean serum vitamin B12 was positively associated with education of the household head and inversely associated with living in the National territories, Eastern or Pacific regions.
The prevalence of vitamin B12 deficiency and marginal deficiency in Colombian women and children is substantial. The burden falls largely on adult women, those with lowest education and those living in the poorest, most rural regions of the country.
维生素B12缺乏与许多不良健康后果相关，在全球范围内高度流行。本研究评估了哥伦比亚儿童和妇女中维生素B12缺乏和边缘缺乏的患病率，并探讨了这些人群血清维生素B12浓度的社会人口学相关因素。
横断面全国代表性调查。
哥伦比亚。
18岁以下儿童（n = 7243）、孕妇（n = 1781）和18 - 49岁非孕妇（n = 499）。
维生素B12缺乏（血清维生素B12 < 148 pmol/l）和边缘缺乏（血清维生素B12 = 148 - 221 pmol/l）的总体患病率分别为6.6%（95%置信区间5.2%，8.3%）和22.5%（95%置信区间21.1%，23.9%）。与非孕成年女性（18.5%；95%置信区间4.4%，53.1%）和儿童（2.8%；95%置信区间2.3%，3.3%）相比，孕妇的缺乏患病率最高（18.9%；95%置信区间16.6%，21.5%）。在儿童的多变量分析中，血清维生素B12均值与女性性别呈正相关（比男性高12 pmol/l；P = 0.004）、户主接受过中等或高等教育（比小学及以下学历高12 pmol/l；P = 0.009）以及粮食安全状况（比严重粮食不安全高21 pmol/l；P = 0.003）。在孕妇的多变量分析中，血清维生素B12均值与户主教育程度呈正相关，与居住在国家领土、东部或太平洋地区呈负相关。
哥伦比亚妇女和儿童中维生素B12缺乏和边缘缺乏的患病率很高。负担主要落在成年女性、教育程度最低的人群以及该国最贫穷、最偏远农村地区的居民身上。
