Division of Nutritional Sciences, Cornell University, Ithaca, NY.
St. John's Research Institute, Bangalore, India.
Trans R Soc Trop Med Hyg. 2018 Oct 1;112(10):423-435. doi: 10.1093/trstmh/try078.
Vitamin B12 deficiency is an urgent public health problem that disproportionately affects individuals in low- and middle-income settings, where the burden of neglected tropical diseases (NTDs) is also unacceptably high. Emerging evidence supports a potential role of micronutrients in modulating the risk and severity of NTDs. However, the role of vitamin B12 in NTD pathogenesis is unknown. This systematic review was conducted to evaluate the evidence on the role of vitamin B12 in the etiology of NTDs. Ten studies were included in this review: one study using an in vitro/animal model, eight observational human studies and one ancillary analysis conducted within an intervention trial. Most research to date has focused on vitamin B12 status and helminthic infections. One study examined the effects of vitamin B12 interventions in NTDs in animal and in vitro models. Few prospective studies have been conducted to date to examine the role of vitamin B12 in NTDs. The limited literature in this area constrains our ability to make specific recommendations. Larger prospective human studies are needed to elucidate the role of vitamin B12 in NTD risk and severity in order to inform interventions in at-risk populations.
维生素 B12 缺乏是一个紧迫的公共卫生问题，在中低收入环境中，它不成比例地影响着人们，而这些地区的被忽视热带病（NTD）负担也高得令人无法接受。新出现的证据支持微量营养素在调节 NTD 风险和严重程度方面的潜在作用。然而，维生素 B12 在 NTD 发病机制中的作用尚不清楚。本系统评价旨在评估维生素 B12 在 NTD 发病机制中的作用的证据。本综述纳入了 10 项研究：一项使用体外/动物模型的研究，八项观察性人类研究和一项干预试验中的辅助分析。迄今为止，大多数研究都集中在维生素 B12 状况和寄生虫感染上。一项研究检验了维生素 B12 干预对动物和体外模型中 NTD 的影响。迄今为止，很少有前瞻性研究来研究维生素 B12 在 NTD 中的作用。该领域的有限文献限制了我们做出具体建议的能力。需要更大规模的前瞻性人类研究来阐明维生素 B12 在 NTD 风险和严重程度中的作用，以便为高危人群的干预提供信息。
