猫局灶性脑缺血中水肿的MRI定量分析：与细胞色素aa3氧化状态的相关性

MRI quantitation of edema in focal cerebral ischemia in cats: correlation with cytochrome aa3 oxidation state.

作者信息

Kline R A, Negendank W G, McCoy L E, Lester M, Berguer R

机构信息

Department of Surgery, Wayne State University, Detroit, Michigan 48201.

出版信息

Magn Reson Med. 1990 Feb;13(2):319-23. doi: 10.1002/mrm.1910130215.

DOI:10.1002/mrm.1910130215

PMID:2156126

Abstract

1H MRI permits detection of edema in the brain. In a middle cerebral artery stroke model in the cat, we found a significant correlation between an edema index based on MRI and a sensitive metabolic index of ischemia, the in vivo oxidation status of mitochondrial cytochrome aa3 determined by near-infrared reflectance spectrophotometry (r = -0.70, alpha = 0.001). This result suggests that a simple, noninvasive study using MRI can provide an index of the extent of ischemic damage in an experimental acute stroke model.

摘要

氢质子磁共振成像（1H MRI）能够检测出脑部水肿。在猫的大脑中动脉卒中模型中，我们发现基于MRI的水肿指数与一种敏感的缺血代谢指数（通过近红外反射分光光度法测定的线粒体细胞色素aa3的体内氧化状态）之间存在显著相关性（r = -0.70，α = 0.001）。这一结果表明，在实验性急性卒中模型中，使用MRI进行的简单、非侵入性研究能够提供缺血性损伤程度的指标。