负压封闭引流技术可促进人工真皮在软组织缺损中的整合：Terudermis(®)和 Pelnac(®)。
Vacuum-assisted closure improves the incorporation of artificial dermis in soft tissue defects: Terudermis(®) and Pelnac(®).
机构信息
Department of Plastic and Reconstructive Surgery, DongGuk University International Hospital, Ilsan, South Korea.
出版信息
Int Wound J. 2011 Jun;8(3):261-7. doi: 10.1111/j.1742-481X.2011.00780.x. Epub 2011 Feb 25.
Abstract
As a dermal scaffold, artificial dermal substitutes allow the body to accomplish its own tissue regeneration through infiltration of cells and neovascularisation. However, they show not only rather lower take rates compared to autologous skin grafts alone, but they also require more time for sufficient vascular ingrowth to overlay the skin graft. To accelerate this overlaying, we applied vacuum-assisted closure negative-pressure settings over the artificial dermis: Terudermis(®) and Pelnac(®) grafts. Fourteen patients with complex tissue defects were treated, including bone exposure in two cases, tendon exposure in seven cases and soft tissue defects in five cases. Nine cases had combined wound infections. The time interval between the first artificial dermis graft and the second split-thickness skin graft over it was 7·64 days on average. Dermal substitutes took place completely in all cases and there were no graft failures.
摘要
作为一种真皮支架，人工真皮替代品允许身体通过细胞浸润和新血管生成来完成自身组织再生。然而，与单独使用自体皮片相比，它们不仅具有较低的吸收率，而且还需要更多的时间来使足够的血管长入覆盖皮片。为了加速这种覆盖，我们在人工真皮上应用了负压封闭负压引流（VAC）装置：Terudermis(®)和 Pelnac(®)移植物。治疗了 14 例复杂组织缺损患者，其中包括 2 例骨外露、7 例肌腱外露和 5 例软组织缺损。9 例合并伤口感染。首次应用人工真皮与再次应用自体刃厚皮片之间的时间间隔平均为 7.64 天。所有病例的真皮替代物均完全替代，无移植物失败。
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