Xiang Mengjie, Kang Qian, Zhang Dawei
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Synth Syst Biotechnol. 2020 Jul 29;5(4):245-251. doi: 10.1016/j.synbio.2020.07.005. eCollection 2020 Dec.
The Gram-positive model bacterium , has been broadly applied in various fields because of its low pathogenicity and strong protein secretion ability, as well as its well-developed fermentation technology. is considered as an attractive host in the field of metabolic engineering, in particular for protein expression and secretion, so it has been well studied and applied in genetic engineering. In this review, we discussed why is a good chassis cell for metabolic engineering. We also summarized the latest research progress in systematic biology, synthetic biology and evolution-based engineering of , and showed systemic metabolic engineering expedite the harnessing for bioproduction.
革兰氏阳性模式细菌，由于其低致病性、强大的蛋白质分泌能力以及成熟的发酵技术，已广泛应用于各个领域。在代谢工程领域，它被认为是一种有吸引力的宿主，特别是在蛋白质表达和分泌方面，因此在基因工程中得到了充分的研究和应用。在这篇综述中，我们讨论了为什么它是代谢工程的良好底盘细胞。我们还总结了其在系统生物学、合成生物学和基于进化的工程方面的最新研究进展，并表明系统代谢工程加速了其在生物生产中的应用。
