纤维性粉尘在实验动物中的致瘤作用。
Tumorigenic effect of fibrous dusts in experimental animals.
作者信息
Pott F, Huth F, Friedrichs K H
出版信息
Environ Health Perspect. 1974 Dec;9:313-5. doi: 10.1289/ehp.749313.
Fibrous dusts (chrysotile, glass fibers, nemalite, palygorscite, and gypsum) and granular dusts (actinolite, biotite, hematite, pectolite, sanidine, and talcum) were injected intraperitoneally into rats. The fibrous dusts (other than gypsum) resulted in a high incidence of mesothelioma (30 - 67%). Gypsum produced only 5% and granular dusts none at all. It is suggested that the fibrous shape leads to a high multiplication rate of cells and predisposes to tumor formation. Fibrosis, in the other hand, does not so predispose. Milled chrysotile with 99.8% fibers than 5 mum in length are carcinogenic in our experience. The carcinogenicity of glass fibers in our experiments may have significance for occupational situations.
将纤维状粉尘（温石棉、玻璃纤维、硅灰石、坡缕缟石和石膏）和颗粒状粉尘（阳起石、黑云母、赤铁矿、硬硅钙石、透长石和滑石）经腹腔注射到大鼠体内。纤维状粉尘（除石膏外）导致间皮瘤的发生率很高（30%-67%）。石膏仅产生5%的间皮瘤，颗粒状粉尘则完全不产生。有人认为，纤维形状会导致细胞增殖率很高，并易引发肿瘤形成。另一方面，纤维化则不易引发肿瘤。根据我们的经验，长度超过5微米的纤维占99.8%的磨碎温石棉具有致癌性。我们实验中玻璃纤维的致癌性可能对职业环境具有重要意义。
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