利用高灵敏度荧光探针检测单个核苷酸位点的 DNA 碱基变异和胞嘧啶甲基化。
Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe.
机构信息
School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
出版信息
Chem Commun (Camb). 2011 Jun 21;47(23):6629-31. doi: 10.1039/c1cc11205h. Epub 2011 May 12.
PMID:21562680
Abstract
A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.
摘要
一种含有通过无核碱基连接体连接的蒽基团的荧光 DNA 探针，可以通过杂交传感测定法在单个位点识别所有四种 DNA 碱基以及表观遗传修饰 C/5-MeC。
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