行为抑制增加背后的脑损伤区域。
Areas of Brain Damage Underlying Increased Reports of Behavioral Disinhibition.
作者信息
Knutson Kristine M, Dal Monte Olga, Schintu Selene, Wassermann Eric M, Raymont Vanessa, Grafman Jordan, Krueger Frank
机构信息
From the Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (KMK, EMW); Dept. of Neuropsychology, University of Turin, Turin, Italy (ODM); INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, ImpAct Team, Lyon, France (SS); University UCBL Lyon 1, Lyon, France (SS); Dept. of Medicine, Imperial College London, London, United Kingdom (VR); Brain Injury Research, Rehabilitation Institute of Chicago, Chicago, IL (JG); Dept. of Physical Medicine and Rehabilitation, Psychiatry and Behavioral Sciences and Cognitive Neurology, Northwestern University Medical School, Chicago, IL (JG); Molecular Neuroscience Dept., George Mason University, Fairfax, VA (FK); and Dept. of Psychology, George Mason University, Fairfax, VA (FK).
出版信息
J Neuropsychiatry Clin Neurosci. 2015 Summer;27(3):193-8. doi: 10.1176/appi.neuropsych.14060126. Epub 2015 May 11.
Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer's disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe's involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior.
脱抑制，即无法抑制不适当行为，见于额颞叶变性、阿尔茨海默病和中风。行为脱抑制会导致社交和情感障碍，包括冲动行为和无视社会习俗。作者调查了177名创伤性脑损伤退伍军人中病变对通过神经精神科问卷测量的行为脱抑制的影响。作者使用MEDx进行基于体素的病变-症状映射。额叶、颞叶、直回和脑岛的损伤与更大程度的行为脱抑制相关，这进一步证明了额叶参与行为抑制，并表明这些区域对于抑制不当行为是必要的。
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