Bukrinskaya A G, Sharova N K
D. I. Ivanovsky Institute of Virology, U.S.S.R. Academy of Medical Sciences, Moscow.
Arch Virol. 1990;110(3-4):287-93. doi: 10.1007/BF01311297.
The treatment of HIV-1 virions with ionic and nonionic detergents (NP 40, octylglucoside, Na deoxycholate) resulted in an effect unusual for enveloped viruses: instead of solubilization of glycoproteins, the core protein p24 was solubilized while envelope glycoproteins with other structural proteins were found in subviral particles. These data are consistent with a model of HIV structural organization in which glycoproteins are included in the matrix formed by the protein p 17 and suggest that p24 is neither involved in the matrix nor closely bound to any viral proteins.
用离子和非离子去污剂（NP 40、辛基葡糖苷、脱氧胆酸钠）处理HIV-1病毒粒子产生了一种对于包膜病毒而言不同寻常的效应：核心蛋白p24被溶解，而不是糖蛋白被溶解，同时包膜糖蛋白与其他结构蛋白存在于亚病毒颗粒中。这些数据与HIV结构组织模型一致，在该模型中糖蛋白包含在由蛋白p17形成的基质中，这表明p24既不参与基质形成，也不与任何病毒蛋白紧密结合。
