Sharova N K, Bukrinskaia A G
Vopr Virusol. 1990 May-Jun;35(3):202-6.
Treatment of virions of human immunodeficiency virus type 1 (HIV-1) with ionic and nonionic detergents (NP-40, octylglucoside, sodium deoxycholate) exerted an effect on the virus uncommon for enveloped viruses: instead of solubilization, both glycoproteins (gp120 and gp41) were found in subviral particles, whereas the core protein p24 was found in the supernatant fluid after the removal of subviral particles by centrifugation. The matrix protein p17 and unprocessed molecules of the precursor protein p55 were associated with subviral particles. The above data confirm the proposed model of the HIV-I structural organization according to which glycoproteins are incorporated into the isometric matrix formed by protein p17. Our data indicate that the core protein p24 is not incorporated into the matrix and not associated with nucleocapsid proteins.
用离子和非离子去污剂（NP - 40、辛基葡糖苷、脱氧胆酸钠）处理1型人类免疫缺陷病毒（HIV - 1）的病毒粒子，对该病毒产生了一种包膜病毒不常见的效应：糖蛋白（gp120和gp41）并未被溶解，而是存在于亚病毒颗粒中，而核心蛋白p24在通过离心去除亚病毒颗粒后的上清液中被发现。基质蛋白p17和前体蛋白p55的未加工分子与亚病毒颗粒相关。上述数据证实了所提出的HIV - 1结构组织模型，即糖蛋白被整合到由蛋白p17形成的等距基质中。我们的数据表明，核心蛋白p24未被整合到基质中，也不与核衣壳蛋白相关。
