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1
Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging.生长激素转基因小鼠骨髓中非常小胚胎样干细胞数量减少，表明慢性升高的Igf1水平会加速多能干细胞池的年龄依赖性耗竭：一种关于衰老的新观点。
Leukemia. 2011 Aug;25(8):1370-4. doi: 10.1038/leu.2011.98. Epub 2011 May 13.
2
The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs).生长激素/胰岛素信号长期存在对成体骨髓中多能性类胚胎极小型干细胞（VSELs）群体产生的负面影响。
Age (Dordr). 2013 Apr;35(2):315-30. doi: 10.1007/s11357-011-9364-8. Epub 2012 Jan 5.
3
A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner?对衰老的一种新见解：成年组织中是否存在多能性的极小型类胚胎干细胞（VSELs），其随时间推移以依赖胰岛素样生长因子-1（Igf-1）的方式耗尽？
Aging (Albany NY). 2010 Nov;2(11):875-83. doi: 10.18632/aging.100231.
4
Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia.骨髓来源的极小胚胎样干细胞在低氧环境下的转录组图谱。
Respir Res. 2011 May 10;12(1):63. doi: 10.1186/1465-9921-12-63.
5
Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.生长激素介导的胰岛素样生长因子-1增加可纠正内皮祖细胞的年龄依赖性损伤。
Circ Res. 2007 Feb 16;100(3):434-43. doi: 10.1161/01.RES.0000257912.78915.af. Epub 2007 Jan 18.
6
Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells.描绘5-氟尿嘧啶和促卵泡激素对小鼠骨髓干/祖细胞的影响。
Stem Cell Res Ther. 2016 Apr 19;7(1):59. doi: 10.1186/s13287-016-0311-6.
7
Mobilization of bone marrow-derived Oct-4+ SSEA-4+ very small embryonic-like stem cells in patients with acute myocardial infarction.急性心肌梗死患者骨髓源性Oct-4+ SSEA-4+ 极小型胚胎样干细胞的动员
J Am Coll Cardiol. 2009 Jan 6;53(1):1-9. doi: 10.1016/j.jacc.2008.09.029.
8
Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction.急性心肌梗死后，骨髓来源的多能性极小型胚胎样干细胞（VSELs）会被动员起来。
J Mol Cell Cardiol. 2008 May;44(5):865-73. doi: 10.1016/j.yjmcc.2008.02.279. Epub 2008 Mar 4.
9
Mouse Bone Marrow VSELs Exhibit Differentiation into Three Embryonic Germ Lineages and Germ & Hematopoietic Cells in Culture.小鼠骨髓 VSELs 在培养中表现出向三种胚胎生殖系和生殖与造血细胞的分化。
Stem Cell Rev Rep. 2017 Apr;13(2):202-216. doi: 10.1007/s12015-016-9714-0.
10
Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in mice.间歇性低氧动员骨髓来源的极小胚胎样干细胞，并在小鼠中激活发育性转录程序。
Sleep. 2010 Nov;33(11):1439-46. doi: 10.1093/sleep/33.11.1439.

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1
Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine.非常小的胚胎样干细胞（VSELs）有望应用于再生医学。
Front Bioeng Biotechnol. 2025 Mar 7;13:1564964. doi: 10.3389/fbioe.2025.1564964. eCollection 2025.
2
Identification of Human Very Small Embryonic like Stem Cells (VSELS) in Human Heart Tissue Among Young and Old Individuals.鉴定年轻和老年个体人心组织中的人类极小胚胎样干细胞（VSELS）。
Stem Cell Rev Rep. 2020 Feb;16(1):181-185. doi: 10.1007/s12015-019-09923-1.
3
Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging.延长的生长激素/胰岛素/胰岛素样生长因子营养反应信号通路是干细胞的沉默杀手和衰老的罪魁祸首。
Stem Cell Rev Rep. 2017 Aug;13(4):443-453. doi: 10.1007/s12015-017-9728-2.
4
A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells.从非常小的胚胎样干细胞静止群体的角度看成人干细胞区室的新观点。
Circ Res. 2017 Jan 6;120(1):166-178. doi: 10.1161/CIRCRESAHA.116.309362.
5
Endothelial progenitor cell levels in juvenile idiopathic arthritis patients: effects of anti-inflammatory therapies.幼年特发性关节炎患者的内皮祖细胞水平：抗炎治疗的影响。
Pediatr Rheumatol Online J. 2015 Feb 19;13:6. doi: 10.1186/s12969-015-0001-4. eCollection 2015.
6
The molecular nature of very small embryonic-like stem cells in adult tissues.成体组织中非常小的胚胎样干细胞的分子本质。
Int J Stem Cells. 2014 Nov;7(2):55-62. doi: 10.15283/ijsc.2014.7.2.55.
7
The proper criteria for identification and sorting of very small embryonic-like stem cells, and some nomenclature issues.鉴定和分选极小胚胎样干细胞的适当标准以及一些命名问题。
Stem Cells Dev. 2014 Apr 1;23(7):702-13. doi: 10.1089/scd.2013.0472. Epub 2014 Jan 11.
8
Very small embryonic-like stem-cell optimization of isolation protocols: an update of molecular signatures and a review of current in vivo applications.非常小的胚胎样干细胞优化分离方案：分子特征的最新更新和当前体内应用的综述。
Exp Mol Med. 2013 Nov 15;45(11):e56. doi: 10.1038/emm.2013.117.
9
Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate.非常小的胚胎样干细胞（VSELs）代表了干细胞生物学中的一个真正挑战：在激烈辩论的过程中，最近出现了正反两方面的观点。
Leukemia. 2014 Mar;28(3):473-84. doi: 10.1038/leu.2013.255. Epub 2013 Sep 10.
10
Genome-wide analysis of murine bone marrow‑derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells.对鼠骨髓来源的极小胚胎样干细胞的全基因组分析表明，有丝分裂原生长因子信号通路在这些细胞的静止和衰老中起着至关重要的作用。
Int J Mol Med. 2013 Aug;32(2):281-90. doi: 10.3892/ijmm.2013.1389. Epub 2013 May 23.

本文引用的文献

1
Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice--novel view on Igf-1, stem cells and aging.循环中胰岛素样生长因子-1（Igf-1）水平低的拉伦侏儒小鼠骨髓中干细胞数量较多——关于Igf-1、干细胞与衰老的新观点
Leukemia. 2011 Apr;25(4):729-33. doi: 10.1038/leu.2010.314. Epub 2011 Jan 14.
2
A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner?对衰老的一种新见解：成年组织中是否存在多能性的极小型类胚胎干细胞（VSELs），其随时间推移以依赖胰岛素样生长因子-1（Igf-1）的方式耗尽？
Aging (Albany NY). 2010 Nov;2(11):875-83. doi: 10.18632/aging.100231.
3
Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells.成年鼠骨髓来源的极小胚胎样干细胞在与 OP9 基质细胞共培养后可分化为造血谱系。
Exp Hematol. 2011 Feb;39(2):225-37. doi: 10.1016/j.exphem.2010.10.007. Epub 2010 Oct 27.
4
The role of telomeres and telomerase in stem cell aging.端粒和端粒酶在干细胞衰老中的作用。
FEBS Lett. 2010 Sep 10;584(17):3826-30. doi: 10.1016/j.febslet.2010.07.042. Epub 2010 Aug 3.
5
Nuclear and chromatin reorganization during cell senescence and aging - a mini-review.细胞衰老和老化过程中的核和染色质重排——综述。
Gerontology. 2011;57(1):76-84. doi: 10.1159/000281882. Epub 2010 Feb 4.
6
Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4(+) very small embryonic-like stem cells.控制成年骨髓来源的Oct4(+) 极小型胚胎样干细胞多能性和静止状态的新型表观遗传机制。
Leukemia. 2009 Nov;23(11):2042-51. doi: 10.1038/leu.2009.153. Epub 2009 Jul 30.
7
Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice.长寿的生长激素受体基因敲除（GHRKO）小鼠、艾姆斯侏儒小鼠以及短命的bGH转基因小鼠的耗氧量、呼吸商和产热的变化。
J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):443-51. doi: 10.1093/gerona/gln075. Epub 2009 Mar 13.
8
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice.生长激素受体/结合蛋白基因敲除小鼠中致命性肿瘤疾病的发病率降低且发病延迟。
J Gerontol A Biol Sci Med Sci. 2009 May;64(5):522-9. doi: 10.1093/gerona/glp017. Epub 2009 Feb 19.
9
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.热量或蛋白质限制对人体血清胰岛素样生长因子-1（IGF-1）和胰岛素样生长因子结合蛋白-3（IGFBP-3）浓度的长期影响。
Aging Cell. 2008 Oct;7(5):681-7. doi: 10.1111/j.1474-9726.2008.00417.x.
10
Endocrine regulation of ageing.衰老的内分泌调节
Nat Rev Mol Cell Biol. 2007 Sep;8(9):681-91. doi: 10.1038/nrm2234.

Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging.

作者信息

Kucia M, Shin D-M, Liu R, Ratajczak J, Bryndza E, Masternak M M, Bartke A, Ratajczak M Z

出版信息

Leukemia. 2011 Aug;25(8):1370-4. doi: 10.1038/leu.2011.98. Epub 2011 May 13.

DOI:10.1038/leu.2011.98
PMID:21566652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3746337/
Abstract
摘要