Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging.
作者信息
Kucia M, Shin D-M, Liu R, Ratajczak J, Bryndza E, Masternak M M, Bartke A, Ratajczak M Z
出版信息
Leukemia. 2011 Aug;25(8):1370-4. doi: 10.1038/leu.2011.98. Epub 2011 May 13.
Abstract
摘要
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1
Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging.生长激素转基因小鼠骨髓中非常小胚胎样干细胞数量减少，表明慢性升高的Igf1水平会加速多能干细胞池的年龄依赖性耗竭：一种关于衰老的新观点。
Leukemia. 2011 Aug;25(8):1370-4. doi: 10.1038/leu.2011.98. Epub 2011 May 13.
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A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner?对衰老的一种新见解：成年组织中是否存在多能性的极小型类胚胎干细胞（VSELs），其随时间推移以依赖胰岛素样生长因子-1（Igf-1）的方式耗尽？
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Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction.急性心肌梗死后，骨髓来源的多能性极小型胚胎样干细胞（VSELs）会被动员起来。
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The molecular nature of very small embryonic-like stem cells in adult tissues.成体组织中非常小的胚胎样干细胞的分子本质。
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Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate.非常小的胚胎样干细胞（VSELs）代表了干细胞生物学中的一个真正挑战：在激烈辩论的过程中，最近出现了正反两方面的观点。
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Genome-wide analysis of murine bone marrow‑derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells.对鼠骨髓来源的极小胚胎样干细胞的全基因组分析表明，有丝分裂原生长因子信号通路在这些细胞的静止和衰老中起着至关重要的作用。
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本文引用的文献
1
Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice--novel view on Igf-1, stem cells and aging.循环中胰岛素样生长因子-1（Igf-1）水平低的拉伦侏儒小鼠骨髓中干细胞数量较多——关于Igf-1、干细胞与衰老的新观点
Leukemia. 2011 Apr;25(4):729-33. doi: 10.1038/leu.2010.314. Epub 2011 Jan 14.
2
A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner?对衰老的一种新见解：成年组织中是否存在多能性的极小型类胚胎干细胞（VSELs），其随时间推移以依赖胰岛素样生长因子-1（Igf-1）的方式耗尽？
Aging (Albany NY). 2010 Nov;2(11):875-83. doi: 10.18632/aging.100231.
3
Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells.成年鼠骨髓来源的极小胚胎样干细胞在与 OP9 基质细胞共培养后可分化为造血谱系。
Exp Hematol. 2011 Feb;39(2):225-37. doi: 10.1016/j.exphem.2010.10.007. Epub 2010 Oct 27.
4
The role of telomeres and telomerase in stem cell aging.端粒和端粒酶在干细胞衰老中的作用。
FEBS Lett. 2010 Sep 10;584(17):3826-30. doi: 10.1016/j.febslet.2010.07.042. Epub 2010 Aug 3.
5
Nuclear and chromatin reorganization during cell senescence and aging - a mini-review.细胞衰老和老化过程中的核和染色质重排——综述。
Gerontology. 2011;57(1):76-84. doi: 10.1159/000281882. Epub 2010 Feb 4.
6
Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4(+) very small embryonic-like stem cells.控制成年骨髓来源的Oct4(+) 极小型胚胎样干细胞多能性和静止状态的新型表观遗传机制。
Leukemia. 2009 Nov;23(11):2042-51. doi: 10.1038/leu.2009.153. Epub 2009 Jul 30.
7
Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice.长寿的生长激素受体基因敲除（GHRKO）小鼠、艾姆斯侏儒小鼠以及短命的bGH转基因小鼠的耗氧量、呼吸商和产热的变化。
J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):443-51. doi: 10.1093/gerona/gln075. Epub 2009 Mar 13.
8
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice.生长激素受体/结合蛋白基因敲除小鼠中致命性肿瘤疾病的发病率降低且发病延迟。
J Gerontol A Biol Sci Med Sci. 2009 May;64(5):522-9. doi: 10.1093/gerona/glp017. Epub 2009 Feb 19.
9
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.热量或蛋白质限制对人体血清胰岛素样生长因子-1（IGF-1）和胰岛素样生长因子结合蛋白-3（IGFBP-3）浓度的长期影响。
Aging Cell. 2008 Oct;7(5):681-7. doi: 10.1111/j.1474-9726.2008.00417.x.
10
Endocrine regulation of ageing.衰老的内分泌调节
Nat Rev Mol Cell Biol. 2007 Sep;8(9):681-91. doi: 10.1038/nrm2234.
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