西苏丹孕妇巨细胞病毒和风疹的血清流行率。
Seroprevalence of cytomegalovirus and rubella among pregnant women in western Sudan.
机构信息
Department of Biochemistry, Faculty of Medicine, Al-Neelain University, Khartoum, Sudan.
出版信息
Virol J. 2011 May 11;8:217. doi: 10.1186/1743-422X-8-217.
BACKGROUND
Maternal cytomegalovirus (CMV) and rubella infections have adverse neonatal outcomes. Basic epidemiological data concerning CMV and rubella is necessary for health planners and care providers.
METHODS
A cross sectional study was conducted at El-Rahad hospital, Sudan to investigate seroprevalence of CMV and rubella infections and associated possible risk factors among pregnant women. Structured questionnaires were used to gather socio-demographic data and ELISA was used to detect CMV and rubella infections using IgG and IgM.
RESULTS
Out of 231 pregnant women, 167 (72.2%) and 151 (65.3%) were CMV-IgG and rubella-IgG positive, respectively. Only 6 (2.5%) and 8 women (3.4%) were CMV-IgM and rubella-IgM positive, respectively. While, high parity (OR = 14.7, 95%CI = 1.7 - 123.6; P = 0.01] and illiteracy (OR = 3.0, CI = 1.4 - 6.5; P = 0.004) were significantly associated with seropostive CMV-IgG in multivariate analysis, none of the other obstetrical and medical characteristics were significantly associated with CMV or rubella infections.
CONCLUSION
CMV prevalence was 72.2% and rubella susceptibility among pregnant women was 34.6%. Rubella vaccine and routine screening for rubella and CMV should be introduced for pregnant women in this setting. Further research is needed.
背景
母体巨细胞病毒（CMV）和风疹感染对新生儿有不良影响。CMV 和风疹的基本流行病学数据对卫生规划人员和医护人员是必要的。
方法
在苏丹的 El-Rahad 医院进行了一项横断面研究，以调查孕妇 CMV 和风疹感染的血清流行率以及相关的可能危险因素。使用结构化问卷收集社会人口统计学数据，使用 ELISA 检测 IgG 和 IgM 以检测 CMV 和风疹感染。
结果
在 231 名孕妇中，167 名（72.2%）和 151 名（65.3%）分别为 CMV-IgG 和风疹 IgG 阳性，仅 6 名（2.5%）和 8 名妇女（3.4%）分别为 CMV-IgM 和风疹 IgM 阳性。而高胎次（OR = 14.7，95%CI = 1.7 - 123.6；P = 0.01）和文盲（OR = 3.0，CI = 1.4 - 6.5；P = 0.004）与 CMV-IgG 血清阳性在多变量分析中显著相关，而其他产科和医学特征均与 CMV 或风疹感染无显著相关性。
结论
CMV 的流行率为 72.2%，孕妇风疹易感性为 34.6%。在这种情况下，应向孕妇引入风疹疫苗和常规风疹及 CMV 筛查。需要进一步研究。
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