纳米药物向实体瘤细胞外和细胞内区室的递送。
Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor.
机构信息
Division of Pharmaceutics, College of Pharmacy, the Ohio State University, Columbus, OH 43210, USA.
出版信息
Adv Drug Deliv Rev. 2012 Jan;64(1):29-39. doi: 10.1016/j.addr.2011.04.006. Epub 2011 May 3.
Abstract
Advances in molecular medicines have led to identification of promising targets on cellular and molecular levels. These targets are located in extracellular and intracellular compartments. The latter include cytosol, nucleus, mitochondrion, Golgi apparatus and endoplasmic reticulum. This report gives an overview on the barriers to delivering nanomedicines to various target sites within a solid tumor, the experimental approaches to overcome such barriers, and the potential utility of nanotechnology.
摘要
分子医学的进步使得在细胞和分子水平上确定有前途的靶点成为可能。这些靶点位于细胞外和细胞内区室中。后者包括细胞质、细胞核、线粒体、高尔基体和内质网。本报告概述了将纳米药物递送至实体瘤内各种靶位的障碍、克服这些障碍的实验方法以及纳米技术的潜在应用。
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Effect of collagenase and hyaluronidase on free and anomalous diffusion in multicellular spheroids and xenografts.胶原酶和透明质酸酶对多细胞球体和异种移植物中自由和异常扩散的影响。
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