父母糖尿病史与 PPP-Botnia 和 Framingham 后代研究中 2 型糖尿病遗传风险评分的关联。
Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies.
机构信息
General Medicine Division, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Diabetes Res Clin Pract. 2011 Aug;93(2):e76-e79. doi: 10.1016/j.diabres.2011.04.013. Epub 2011 May 12.
Abstract
OBJECTIVE
Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown.
METHODS
We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study).
RESULTS
Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend)=0.03). The trend was similar among Framingham Offspring but was not statistically significant (p=0.07). The meta-analyzed p value for trend from the two studies was 0.005.
CONCLUSIONS
The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors.
摘要
目的
糖尿病家族史和特定基因变异是 2 型糖尿病的风险因素，但这些因素的关联程度尚不清楚。
方法
我们在两项来自芬兰（基于人群的 PPP-Botnia 研究）和美国（基于家族的 Framingham Offspring 研究）的队列研究中，研究了糖尿病家族史与 2 型糖尿病遗传风险评分（GRS）之间的关系。
结果
PPP-Botnia 参与者中，GRS 分别为 0、1 和 2 个父母患有糖尿病，其平均值（95%CI）从 16.8（16.8-16.9）增加到 16.9（16.8-17.1）再增加到 17.1（16.8-17.4）（趋势 p=0.03）。Framingham Offspring 中的趋势相似，但无统计学意义（p=0.07）。两项研究的荟萃分析趋势 p 值为 0.005。
结论
上述报告的非常轻微的关联表明，父母患有糖尿病的子女患糖尿病的风险增加主要是由于共同的环境/生活方式因素和/或尚未知晓的遗传因素所致。
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2
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3
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5
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7
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9
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10
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