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肺炎支原体诱发小鼠肺炎对其后续抵抗细菌感染能力的影响以及仙台病毒呼吸道感染对小鼠抵抗肺炎支原体能力的影响。

The effect of pneumonia induced in mice with Mycoplasma pulmonis on resistance to subsequent bacterial infection and the effect of a respiratory infection with Sendai virus on the resistance of mice to Mycoplasma pulmonis.

作者信息

Howard C J, Stott E J, Taylor G

出版信息

J Gen Microbiol. 1978 Nov;109(1):79-87. doi: 10.1099/00221287-109-1-79.

DOI:10.1099/00221287-109-1-79
PMID:215702
Abstract

The effect of pneumonia induced by Mycoplasma pulmonis in mice on the resistance of the lung to additional bacterial infection was examined. The effect of pneumonia induced by Sendai virus on the resistance of mice to M. pulmonis was also investigated and compared with the effect of Sendai virus on resistance to Staphylococcus aureus. Sendai virus infection decreased subsequent resistance to M. pulmonis in proportion to the virus dose. Decreased resistance to subsequent S. aureus and M. pulmonis infection was greatest at about the same time after inoculation of virus and was related to virus-induced lesions. Besides affecting the resistance of mice to subsequent mycoplasma infection, Sendai virus could enhance an existing mycoplasma infection. Pneumonia induced by M. pulmonis did not decrease resistance to subsequent bacterial infection. The mechanism whereby Sendai virus decreases host resistance is therefore similar for bacteria and mycoplasmas, but pneumonia induced by mycoplasmas does not have the same effect.

摘要

研究了肺支原体诱导的小鼠肺炎对肺抵抗额外细菌感染能力的影响。还研究了仙台病毒诱导的肺炎对小鼠抵抗肺支原体能力的影响，并与仙台病毒对抵抗金黄色葡萄球菌能力的影响进行了比较。仙台病毒感染会使随后对肺支原体的抵抗力按病毒剂量成比例下降。接种病毒后大约相同时间，对随后金黄色葡萄球菌和肺支原体感染的抵抗力下降最大，且与病毒诱导的病变有关。除了影响小鼠对随后支原体感染的抵抗力外，仙台病毒还可增强现有的支原体感染。肺支原体诱导的肺炎并未降低对随后细菌感染的抵抗力。因此，仙台病毒降低宿主抵抗力的机制对于细菌和支原体是相似的，但支原体诱导的肺炎没有相同的效果。

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