Department of Animal Production, Faculty of Veterinary Medicine, University of Bari Aldo Moro, Strada Prov. le per Casamassima, Valenzano, Bari, Italy.
Anim Reprod Sci. 2011 Jun;126(1-2):19-22. doi: 10.1016/j.anireprosci.2011.04.013. Epub 2011 Apr 29.
Bovine follicular cysts are an ovarian disorder of dairy cows associated with abnormal estrous behaviour and infertility. The treatment of choice is intramuscular administration of a GnRH analogue, which acts by triggering pituitary release of LH. However, the presence of GnRH and GnRH receptors on spinal cord and ovary in some species, and the kind of innervation of the ovary, let us hypothesize that GnRH and its analogues may also act when administered by epidural route, as happens for other drugs. Therefore the aim of this study was to compare the effects of epidural vs intramuscular administration of lecirelin (a GnRH analogue) on FC regression, estrus detection and pregnancy outcomes. The study was conducted on 220 Friesian cows affected by follicular cysts, divided among 4 groups: Group L(epid) and Group L(im) received, respectively 50 μg of lecirelin in the epidural space and intramuscular; Group C(epid) and Group C(im) were used as control groups. In Group L(epid), estrus induction and pregnancy rates were significantly higher than in Group L(im). The results of this study show that the epidural administration of lecirelin promoted the remission of follicular cysts and an improvement of reproductive parameters compared to intramuscular administration. Thus, an alternative therapeutical approach is available for FC treatment, in order to obtain an easier restoration of the ovarian activity, especially in those cases refractory to classical therapeutic approaches.
牛卵泡囊肿是奶牛的一种卵巢疾病，与异常发情行为和不孕有关。治疗的首选方法是肌肉内注射 GnRH 类似物，它通过触发垂体释放 LH 起作用。然而，在某些物种的脊髓和卵巢上存在 GnRH 和 GnRH 受体，以及卵巢的神经支配方式，让我们假设 GnRH 及其类似物也可能在通过硬膜外途径给药时起作用，就像其他药物一样。因此，本研究旨在比较硬膜外和肌肉内给予 lecirelin（一种 GnRH 类似物）对 FC 消退、发情检测和妊娠结果的影响。该研究在 220 头患有卵泡囊肿的弗里西亚奶牛中进行，分为 4 组：L 组（硬膜外）和 L 组（肌肉内）分别在硬膜外腔和肌肉内给予 50 μg lecirelin；C 组（硬膜外）和 C 组（肌肉内）作为对照组。在 L 组（硬膜外）中，发情诱导和妊娠率明显高于 L 组（肌肉内）。这项研究的结果表明，与肌肉内给药相比，硬膜外给予 lecirelin 促进了卵泡囊肿的消退和生殖参数的改善。因此，为了更轻松地恢复卵巢活动，特别是对于那些对经典治疗方法有抗药性的病例，一种替代治疗方法是可行的。
