IEEE Trans Biomed Eng. 2011 Aug;58(8). doi: 10.1109/TBME.2011.2153851. Epub 2011 May 12.
The ability to measure in vivo strain and strain rate in embryonic chick heart is one of the key requirements for understanding the mechanisms of cardiac development. Due to its high temporal and spatial resolution as well as its fast imaging capability, optical coherence tomography (OCT) has the potential to reveal the complex myocardial activity in the living chick heart. We describe a method to evaluate the in vivo strain and strain rate of the myocardium through analyzing the periodic variation of the myocardial wall thickness calculated from real time serial OCT images. The results demonstrate that OCT can be a useful tool to describe the biomechanical characteristics of the embryonic heart.
能够在胚胎鸡心中测量体内应变和应变速率是理解心脏发育机制的关键要求之一。由于其具有高时间和空间分辨率以及快速成像能力,光学相干断层扫描(OCT)有可能揭示活体鸡心中复杂的心肌活动。我们描述了一种通过分析实时序列 OCT 图像计算得到的心肌壁厚度周期性变化来评估心肌体内应变和应变速率的方法。结果表明,OCT 可以成为描述胚胎心脏生物力学特性的有用工具。