Tumilowicz J J, Latlief M A
J Med Virol. 1978;3(2):151-6. doi: 10.1002/jmv.1890030209.
The effect of urea on plaque formation by herpes simplex virus type 2 (HSV-2) was examined in two systems at concentrations within or approximating the range found in human urine. Approximately 7--10 mg urea/ml, added 2, 4, or 8 hours after infection, reduced plaque formation by 50% in African green monkey kidney cells. The growth of this system was affected slightly by continuous treatment with urea at 7--10 mg/ml. Plaque formation was reduced in the monkey kidney system, albeit diminishingly, even after addition of urea 12 hours after infection. In the human lung fibroblast system, urea at 10 mg/ml reduced plaque numbers by 50% but depressed the growth of cells completely.
在两个系统中，研究了尿素对2型单纯疱疹病毒（HSV - 2）斑块形成的影响，其浓度处于或接近人尿液中的浓度范围。在感染后2、4或8小时添加约7 - 10毫克尿素/毫升，可使非洲绿猴肾细胞中的斑块形成减少50%。用7 - 10毫克/毫升的尿素持续处理对该系统的生长有轻微影响。即使在感染后12小时添加尿素，猴肾系统中的斑块形成也会减少，尽管减少程度逐渐变小。在人肺成纤维细胞系统中，10毫克/毫升的尿素可使斑块数量减少50%，但会完全抑制细胞生长。
