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在一家三级护理医院的重症监护区域产金属β-内酰胺酶的铜绿假单胞菌和不动杆菌属的患病率。

Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital.

作者信息

De Anuradha S, Kumar Simit H, Baveja Sujata M

机构信息

Department of Microbiology, L.T.M. Medical College, Mumbai, India.

出版信息

Indian J Crit Care Med. 2010 Oct;14(4):217-9. doi: 10.4103/0972-5229.76089.

DOI:10.4103/0972-5229.76089
PMID:21572756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3085226/
Abstract

A total of 39 non-duplicate isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter species isolated from blood and endotracheal secretions were tested for metallo-β-lactamase (MBL) production by modified-EDTA disc synergy and double disc synergy tests. The prevalence of MBLs was 33.33% by both the above tests. All patients with MBL-positive isolates were multidrug resistant and had multiple risk factors like > 8 days hospital stay, catheterization, IV lines, previous antibiotic use, etc. These were risk factors for imipenem resistance also. The overall mortality in MBL-positive patients was 46.15%.

摘要

对从血液和气管分泌物中分离出的39株非重复的耐碳青霉烯类铜绿假单胞菌和不动杆菌属菌株进行了检测，通过改良EDTA纸片协同试验和双纸片协同试验检测金属β-内酰胺酶（MBL）的产生情况。上述两种试验检测出MBL的流行率均为33.33%。所有MBL阳性菌株的患者均对多种药物耐药，且有多种危险因素，如住院时间>8天、插管、静脉输液、既往使用抗生素等。这些也是亚胺培南耐药的危险因素。MBL阳性患者的总死亡率为46.15%。

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